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Saiba tudo sobre Câncer de estômago

O câncer de estômago também é chamado de câncer gástrico. O tipo adenocarcinoma é responsável por cerca de 95% dos casos de tumor do estômago.

Outros tipos de tumores, como linfomas e sarcomas, também podem ocorrer no estômago. Os linfomas são diagnosticados em cerca de 3% dos casos. Sarcomas são tumores raros, iniciados nos tecidos que dão origem a músculos, ossos e cartilagens. Um tipo que pode afetar o estômago é o tumor estromal gastrointestinal, mais conhecido como GIST.

O adenocarcinoma de estômago atinge, em sua maioria, homens por volta dos 60-70 anos. Cerca de 65% dos pacientes têm mais de 50 anos.

No Brasil, o câncer de estômago é o terceiro tipo mais frequente entre homens e o quinto entre as mulheres.

Atenção: As informações neste portal pretendem apoiar e não substituir a consulta médica. Procure sempre uma avaliação no Serviço de Saúde.

Estatísticas

Estimativas de novos casos: 21.290, sendo 13.540 homens e 7.750 mulheres (2018 – INCA).

Número de mortes: 14.314, sendo 9.207 em homens e 5.107 mulheres (2017 – SIM)

O que aumenta o risco?

  • Excesso de peso e obesidade
  • Consumo de álcool
  • Consumo excessivo de sal, alimentos salgados ou conservados no sal
  • Tabagismo
  • Ingestão de água proveniente de poços com alta concentração de nitrato
  • Doenças pré-existentes, como anemia perniciosa, lesões pré-cancerosas (como gastrite atrófica e metaplasia intestinal) e infecções pela bactéria Helicobacter pylori (H. pylori)
  • Combinação de tabagismo com bebidas alcoólicas ou com cirurgia anterior do estômago
  • Exposição ocupacional à radiação ionizante, como raios X e gama, em indústrias ou em instituições médicas
  • Exposição de trabalhadores rurais a uma série de compostos químicos, em especial agrotóxicos
  • Exposição ocupacional, na produção da borracha, a vários compostos químicos, muitos classificados como reconhecidamente cancerígenos, como benzeno, óleos minerais, produtos de alcatrão de hulha, compostos de zinco e uma série de pigmentos
  • Ter parentes de primeiro grau com câncer de estômago

Como prevenir?

Para prevenir o câncer de estômago recomenda-se manter o peso corporal dentro dos limites da normalidade, evitar o consumo de bebidas alcoólicas e de alimentos salgados e preservados em sal.

Também é importante não fumar.

Sinais e sintomas

Não há sintomas específicos do câncer de estômago. Porém, alguns sinais, como perda de peso e de apetite, fadiga, sensação de estômago cheio, vômitos, náuseas e desconforto abdominal persistente podem indicar tanto uma doença benigna (úlcera, gastrite, etc.) como um tumor de estômago. Durante o exame físico, o paciente com câncer pode sentir dor no momento em que o estômago é palpado.

Sangramentos gástricos são incomuns no câncer de estômago, entretanto, o vômito com sangue ocorre em cerca de 10% a 15% dos casos. Também podem surgir sangue nas fezes, fezes escurecidas, pastosas e com odor muito forte (indicativo de sangue digerido).

Massa palpável na parte superior do abdômen, aumento do tamanho do fígado e presença de íngua na área inferior esquerda do pescoço e nódulos ao redor do umbigo indicam estágio avançado da doença.

Detecção precoce

A detecção precoce do câncer é uma estratégia para encontrar um tumor em fase inicial e, assim, possibilitar maior chance de tratamento.
A detecção pode ser feita por meio da investigação com exames clínicos, laboratoriais ou radiológicos em pessoas com sinais e sintomas sugestivos da doença (diagnóstico precoce), ou com exames periódicos em pessoas sem sinais ou sintomas (rastreamento), mas pertencentes a grupos com maior chance de ter a doença.
Não há evidência científica de que o rastreamento do câncer de estômago traga mais benefícios do que riscos e, portanto, até o momento, ele não é recomendado.
Já o diagnóstico precoce desse tipo de câncer possibilita melhores resultados em seu tratamento e deve ser buscado com a investigação de sinais e sintomas como:

  • Massa (tumor) na parte superior do abdômen
  • Dor na parte superior do abdômen
  • Perda de peso e de apetite
  • Refluxo e indigestão

Na maior parte das vezes, esses sintomas não são causados por câncer, mas é importante que eles sejam investigados por um médico, principalmente se não melhorarem em alguns dias.

Diagnóstico

O diagnóstico é feito pela endoscopia digestiva alta. Para realizar esse exame, o paciente recebe sedação e é aplicado anestésico na região da garganta. A seguir, um tubo é introduzido pela boca. A endoscopia digestiva alta permite ao médico visualizar o esôfago e o estômago, além de fazer biópsias (retirada de pequenos fragmentos do tecido). O material da biópsia é enviado a um laboratório para que seja confirmado (ou não) o diagnóstico de tumor maligno e definido qual o tipo de tumor.

Caso o diagnóstico de câncer gástrico seja confirmado, geralmente é necessária a realização de tomografias computadorizadas para avaliar a extensão do tumor. Em alguns casos, quando o câncer parece ser de estágio mais inicial, pode ser solicitada ultrassonografia endoscópica (exame semelhante à endoscopia digestiva alta, em que na ponta do tubo introduzido pela garganta há um aparelho de ultrassom).

Tratamento

– Doença localizada
O câncer de estômago é considerado localizado quando está restrito ao órgão e aos gânglios linfáticos ao redor. Neste caso, o principal tratamento é a cirurgia. Durante o procedimento, o cirurgião primeiramente faz um exame visual do interior da cavidade abdominal, para verificar se não há disseminação do tumor que não foi constatada nos exames pré-operatórios. A decisão de retirar todo o estômago ou apenas parte dele depende de fatores como a localização específica do tumor, a extensão da lesão e o subtipo de câncer. Em algumas situações, como quando o tumor invade a artéria aorta, a cirurgia pode não ser possível.

A realização da quimioterapia, antes e/ou após a cirurgia, em geral, aumenta as chances de cura (exceto nos tumores mais iniciais). Em casos selecionados, também pode ser necessário o tratamento com radioterapia após a cirurgia.

– Câncer inoperável ou metastático

Nas situações em que não é possível retirar o tumor com cirurgia ou em que há metástases (câncer espalhado para outros órgãos), o tratamento é paliativo. As metástases do câncer gástrico em geral estão localizadas no peritônio (membrana que recobre os órgãos digestivos e a parede interna da cavidade abdominal), fígado, pulmões, ossos, gânglios linfáticos distantes do estômago, cérebro e glândula adrenal.

O objetivo do tratamento paliativo é aliviar ou evitar sintomas, melhorar a qualidade de vida e prolongar a sobrevida. A escolha do tipo de tratamento paliativo depende dos sintomas presentes, da extensão do tumor e, principalmente, das condições físicas do paciente.

O sangramento tumoral em geral é de pequena quantidade e crônico, mas, em alguns casos, pode ser mais agudo. A avaliação médica define o tratamento necessário para cada paciente, que pode incluir: observação, medicamentos, transfusões sanguíneas, procedimentos endoscópicos ou vasculares (embolização para cessar o sangramento), cirurgia ou radioterapia paliativa.

Outros sintomas frequentes são náuseas, vômitos, caquexia e a obstrução do trânsito intestinal. Em casos mais brandos, modificações de dieta e o uso de medicamentos podem aliviar. Em outras situações, a depender da causa da obstrução e das condições físicas do paciente, a melhora pode ocorrer com quimioterapia, radioterapia, procedimentos endoscópicos ou cirúrgicos. A colocação de um cateter pelo nariz até o estômago para fazer a descompressão gástrica e a drenagem de secreção, ou mesmo a sedação paliativa, podem ser necessários em quadros clínicos mais graves.

A quimioterapia paliativa pode, em alguns casos, prolongar a sobrevida e melhorar a qualidade de vida. É importante que esse tratamento seja feito de forma simultânea ao controle dos sintomas (medidas para controle de dor, sangramento, vômitos, etc.) e do suporte psicossocial ao paciente e familiares.

– Linfoma gástrico 

O tratamento, que depende do tipo de linfoma e da extensão da doença, pode incluir uma ou mais das seguintes modalidades: tratamento da infecção pela H. pylori; cirurgia; radioterapia; quimioterapia; anticorpo contra linfócitos B.

– GIST

O tratamento pode incluir cirurgia e uso de medicamentos via oral.

Fonte: Inca – Instituto Nacional de Câncer

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